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Mass Spectrometry Facilities
Chemistry Building, Rm. R403 55 North Eagleville Road University of Connecticut Storrs, CT 06269 Q-TOF2 Dr. You-Jun Fu Phone: (860) 486-5839 Fax: (860) 486-2981 Email: You-Jun.Fu@uconn.edu Dr. Dennis Hill Phone: (860) 486-4265 Fax: (860) 486-4998 Email: Dennis.Hill@Uconn.edu Dr. David F. Grant Phone: (860) 486-4265 Fax: (860) 486-4998 Email: David.Grant@Uconn.edu Advanced Technology Laboratory Building, Rm. 207 1392 Storrs Road Storrs, CT 06269 University of Connecticut Gilson Preparative HPLC-SPE & Shimadzu Nexera LCMS Dr. Bradley Bolling Phone: (860) 486-2180 Fax: (860) 486-3674 Email: Bradley.Bolling@Uconn.edu Dr. Richard Bruno Phone: (860) 486-1608 Fax: (860) 486-3674 Email: Richard.Bruno@Uconn.edu |
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About Us
Research Potential
InstrumentationThe Mass Spectrometry Facility is equipped with the following instrumentation:
Q-TOF2 Spectrometer: equipped with an API ionization source that operates in either electrospray (ESI) or atmospheric pressure chemical ionization (APcI) mode useful for a broad range of molecules to ~12 kDa. This instrument is capable of precision mass determination as well as structural elucidation by tandem mass spectrometry (MS/MS). A dedicated HPLC affords compound separation in mixtures.
Gilson Preparative HPLC-SPE System: equipped with low- and high-pressure binary gradient pumps, a 2-channel UV/Vis detector, and an automated liquid handler capable of fraction collection, injection, re-injection, and sample extraction, and an integrated SPE module for automated sample clean up and injection. This instrument complements mass spectrometry analysis by enabling purification of food extracts, isolating metabolites of bioactive agents, recombinant proteins, and biomarkers implicated in chronic disease.
Shimadzu Nexera LCMS Ultra High-performance Liquid Chromatography System: equipped with an inline single quadrupole mass spectrometer and photodiode array detectors (UPLC-MS-PDA) that provides rapid, precise, and sensitive capabilities for measuring dietary bioactive food components and biomarkers implicated in nutrition-related diseases.
Cost for ServicesCurrent pricing for services can be found at: http://www.biotech.uconn.edu/msf/pdf/msf-feeschedule.pdf. All rates are subject to periodic review and change. For specific price information contact the Facility Scientists.
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The Mass Spectrometry Facility was first established in 2007 with two mass spectrometers located in the Chemistry Building, Room R403. With continued support through the VPR’s 2010 Major Equipment Competition, a second facility was added in the Advanced Technology Laboratory (ATL) Building in 2011 for the support of research in the areas of clinical biomarkers and nutrition-related research. The establishment of these two facilities recognizes the increasingly important role of mass spectrometry in accomplishing research related to the analysis of small molecules, protein structure, compound purity and identity, analytical aspects of drug design, and quantifying health promoting bioactive food components as well as biomarkers of disease.
The Mass Spectrometry Facility serves the analytical needs of a diverse group of investigators from Molecular & Cell Biology, Chemistry, Nutrition, Chemical Engineering, Animal Sciences, Plant Sciences, Anthropology, Geology, Pharmacy, the UConn Health Center, the UConn Marine Sciences Program at Avery Point, and the UConn Institute of Material Sciences. External users include Central and Eastern Connecticut State Universities, Connecticut College, Connecticut Agricultural Experiment Station, Connecticut Forensic Laboratory, and several private sector corporations. Services, consultations, and guidance are provided by the Facility Co-heads and Scientists.
